The Interesting Ways Ketamine Rewires the Brain

a lovely lady suffering from a headache
a lovely lady suffering from a headache

The Interesting Ways Ketamine Rewires the Brain

There are many ways that Ketamine affects the brain. For many years now, Ketamine therapy has shown great potential in treating both neurological and psychiatric disorders. Studies on Ketamine and mental illness show that even one treatment can provide incredible, instantaneous, and lasting relief. As ongoing research uncovers even more benefits for the mind, the popularity of Ketamine continues to rise. Read on to learn about the interesting ways Ketamine rewires the brain.

How Ketamine Rewires the Brain

Ketamine clinics are popping up nationwide with the rise in popularity. However, Ketamine therapy is still relatively new. One of the many reasons people are turning to Ketamine is its unique effect on the mind. Here are a few of the most exciting ways Ketamine affects the brain.


How Ketamine increases glutamate in the brain is perhaps the most breakthrough research being done on this treatment. Glutamate is the most abundant excitatory neurotransmitter in the brain and plays a critical role in many essential brain functions, such as learning, memory, neuroplasticity, mood regulation, and motor control.
Studies show Ketamine releases glutamate in the prefrontal cortex and other brain regions. This increase in glutamate can help patients make lasting changes and respond well to new experiences.

In an article published by Harvard Medical School, Dr. Robert C. Meisner explained more about Ketamine and glutamate. He wrote: “One likely target for Ketamine is NMDA receptors in the brain. By binding to these receptors, Ketamine appears to increase the amount of a neurotransmitter called glutamate in the spaces between neurons…this process likely affects mood, thought patterns, and cognition.” 1


Studies also show Ketamine to increase BDNF, Brain-Derived Neurotrophic Factor, positively. BDNF is an essential protein that affects the development, growth, and maintenance of neurons in the brain. Like glutamate, BDNF also plays a vital role in cognitive function, memory, and mood regulation. Additionally, studies show that higher levels of BDNF can decrease the risk of developing mood disorders.

mTOR Pathway

Ketamine has been shown to activate the mTOR pathway, which is a cellular signaling pathway involved in regulating protein synthesis and cell growth. One study suggests that the effect Ketamine has on the mTOR pathway contributes to its quick antidepressant results. In this same study, researchers state that “The rapid antidepressant response after Ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood disorders compared to the weeks or months required for standard medications.” 2

Other Neurotransmitters

Ketamine has been found to affect other neurotransmitter systems in the brain, including dopamine, serotonin, and acetylcholine. For example, Ketamine has been found to increase dopamine release in certain brain regions, which may contribute to its mood-elevating effects.

The Many Treatment Applications offered at Ketamine LA Therapy

Rewiring the brain can solve a myriad of mental health disorders and physical conditions. Ketamine Therapy LA is the trusted Ketamine provider in West Hollywood and Los Angeles. These are some of the conditions we expertly treat with Ketamine.

Ketamine for Anxiety

Anxiety plagues more than 40 million people in the United States. With Valium (commonly prescribed for anxiety), the anti-anxiety effects will only last while the medication is in your system. Once gone, it is very possible to get ‘rebound anxiety’.

Ketamine for Depression

For those specifically struggling with treatment-resistant depression, Ketamine may be right for you. Where SSRIs (like Zoloft or Prozac) can take some time to work, Ketamine has an almost instant effect. Many patients report relieved feelings of fatigue and sadness for up to a week after just one treatment.

Ketamine for PTSD

PTSD symptoms often include depression and memory impairment. As Ketamine increases glutamate and improves other functions of neurotransmitters, it is an ideal treatment for PTSD. Dr. Prakash Masand (chairman of COPE) states that “30-40 percent of PTSD is treatment-resistant to commonly used treatments and needs innovative treatments. An innovative treatment for PTSD cases that don’t respond well to traditional treatments is Ketamine IV infusions. The benefits of Ketamine are substantial…” 3

Ketamine for OCD

Ketamine for OCD is being studied widely, as there are few solutions available now. Those that have opted for Ketamine treatments for OCD have reported a loss of compulsion during their first infusion- a huge feat, especially for anyone desperate for relief.

Ketamine for Addiction

In a study done recently by the New York State Psychiatric Institute, researchers state that Ketamine “significantly increased the likelihood of abstinence, delayed the time to relapse, and reduced the likelihood of heavy drinking days”.

Ketamine for Chronic Pain

Chronic pain and depression often occur hand-in-hand. Studies are showing Ketamine to be just as, sometimes more, beneficial than opioid medication typically prescribed for chronic pain. Ketamine treatments offer significant pain relief in addition to a significant improvement in symptoms of depression.

Ultimately, Ketamine’s effect on the brain is extremely nuanced and complex. More research and study are required for providers and patients to understand it better. However, with our current information, Ketamine treatment is already a revolutionary step toward mental wellness. With such promising benefits for the brain, it is no wonder Ketamine therapy is becoming so popular.

Although Ketamine is not the cure for all mental health conditions, it is a promising path to helping you regain your life. Traditional medications have many drawbacks and spotty, sometimes dangerous effects. The Ketamine difference is stark and full of unique benefits for the mind.

Rewire Your Brain with Ketamine in LA

Discover the ways Ketamine can rewire your brain today. Contact Ketamine Therapy LA today. As the leading provider of Ketamine Therapy in West Hollywood, CA, we provide safe and effective treatments. We are dedicated to helping you gain a new lease on life with the long-lasting benefits possible with Ketamine. Book a consultation with us today to discover if Ketamine therapy suits you. Call 323-650-9883 to get started.

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Ketamine and Lamar Odom | Re/Born | New Documentary on Ketamine

Lamar Odom smiling after Ketamine Treatment.
Lamar Odom smiling after Ketamine Treatment.

Ketamine and Lamar Odom | Re/Born | New Documentary on Ketamine

In the new documentary, “Lamar Odom Re/Born,” the famous basketball player credits Ketamine, a revolutionary drug therapy, for his recovery from addiction, anxiety, and depression.

The documentary follows Odom as he goes through a curated therapy, which includes Ketamine injections, to work through past traumas and overcome self-defeating coping mechanisms.

Learn more about Ketamine Therapy >>

Lamar Odom and Ketamine

Odom’s journey to recovery, the theme of the new documentary, follows a near-death experience. In 2015, Odom was found unresponsive in a Las Vegas brothel. Odom suffered numerous heart attacks and strokes and spent several days in a coma after overdosing on cocaine.

Obviously, Odom survived. Doctors called him a walking miracle. His near-death experience was the catalyst that pushed Odom to change his life.

Odom told Good Morning America, “I went to rehab and did some other things, but ketamine came into my life at the right time.” He continues saying, “I’m feeling amazing…I’m alive. I’m sober. I’m happy.”

Odom further says that he attends to incorporate Ketamine therapy into his healthy living regime. “I don’t think I will stop it,” he said of the drug. “I wouldn’t want to try to stop…”

What is Ketamine?

Ketamine is a synthetic drug. The FDA first approved it in the 1970s as a short-acting anesthetic. Unfortunately, its psychedelic side effects made Ketamine a coveted party drug known as Special K.

However, over the years, comprehensive medical research demonstrated Ketamine’s effectiveness for improving treatment-resistant depression. The research was so promising that the Cleveland Clinic distinguished Ketamine as one of the most “innovative medical treatments of 2017” and earned “breakthrough” status for the drug by the FDA.

The National Institute of Mental Health director, Thomas Insel, MD, backed up the research saying, “Recent data suggest that ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades.”

What is Ketamine Therapy?

Currently, Ketamine,  injected in small amounts, provides an “off-label use” for depression, suicidality, anxiety, PTSD, and addiction. In 2019, the FDA approved a nasal spray form of Ketamine, known as Esketamine, for treatment-resistant depression.

During a Ketamine treatment from Cosmetic Rejuvenation Medical Center, Board-certified anesthesiologist, Dr. Sirak administers small doses of Ketamine in a comfortable, clinical setting.

Ketamine takes effect almost immediately and wears off within an hour or so after the injection or infusion. During the treatment, many patients experience an altered mental state. However, patients are still able to talk and walk.

For some patients, especially those who are experiencing suicidal feelings, Ketamine brings relief almost immediately.

Ketamine is best used in conjunction with a comprehensive treatment.

Ketamine Treatment Near Me | Los Angeles

Learn more about this innovative therapy to alleviate depression, anxiety, and addiction. Get started by scheduling a consultation with the medical professionals at Cosmetic Rejuvenation Medical Center. Reach out online by filling out the form below or call Cosmetic Rejuvenation Medical Center at 323-650-9883.

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H, Choo T, et al. Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial. Am J Psychiatry. 2018;175(4):327-335. Link.

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Ketamine Treatment for Depression | Revolutionary Depression Treatment

Ketamine Treatment for Depression | Revolutionary Depression Treatment

Ketamine treatment for depression is a promising new therapy for improving treatment-resistant depression. Read on to learn more about the new depression treatment that the Cleveland Clinic calls one of the most “innovative medical treatments of 2017.”

Learn more about Ketamine Therapy >>

What is Ketamine Treatment?

Ketamine is a synthetic drug that was first found use on the battlefield as a short-lasting anesthetic. However, more and more clinical evidence emerges suggesting Ketamine to be a fast-acting treatment for the alleviation of severe depression and thoughts of suicide for individuals who do not respond to other treatments.

When used in therapeutic situations, Ketamine can be used off-label for various conditions and symptoms. These include:

  • Depression
  • Treatment-resistant depression
  • Suicidal ideation
  • Bipolar disorder
  • Anxiety
  • PTSD
  • Addiction
  • Obsessive-Compulsive Disorder (OCD)
  • Migraines
  • Chronic pain

Ketamine also comes in a nasal spray, known as Esketamine. This form of Ketamine is FDA-approved specifically for treatment-resistant depression.

How Does Ketamine Work?

Ketamine is not like your traditional SSRIs (such as Zoloft or Prozac) or Benzodiazepines (Valium or Xanax), which are commonly prescribed for depression and anxiety. This is why researchers consider the discovery of Ketamine as “a new, rapidly acting class of drug with a completely novel mechanism” as “arguably the biggest breakthrough in the field of depression in over 60 years.”

Dr. John Krystal, chief psychiatrist at Yale Medicine and one of the pioneers of ketamine research, further explains the difference between Ketamine and traditional drugs for depression and anxiety. He comments, “with most medications, like Valium, the anti-anxiety effect you get only lasts when it is in your system. When the valium goes away, you can get rebound anxiety.” In comparison, Dr. Krystal explains, “When you take Ketamine, it triggers reactions in your cortex that enable brain connections to regrow. It’s the reaction to Ketamine, not the presence of Ketamine in the body that constitutes its effects.”

Antidepressants regulate chemicals in the brain. Ketamine does not influence those chemicals. Instead, Ketamine promotes the production of glutamate. Glutamate impacts neuroplasticity. It allows the brain to physically restructure itself by creating new neuropathways. In other words, Ketamine enables the brain to “rewire” itself. Ketamine helps create new pathways (that facilitate new ways of thinking) which are resilient to depression, stress, and anxiety.

Ketamine’s novel mechanism of action is one reason why it helps people who do not respond to anti-depressants.

Fast-acting relief

Another advantage of Ketamine for depression is its near-instantaneous effects. This fast-acting drug can relieve suicidal thoughts and symptoms of severe depression within hours of the injection. This is quite different from traditional SSRIs that can take weeks to months to take effect.

Ketamine Treatment Near Me

Find out if Ketamine treatment for depression is right for you. Get started by contacting Cosmetic Rejuvenation Medical Center, the leading Ketamine clinic in Los Angeles. Reach out online by completing the form below or call the clinic at 323-650-9883.

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Duman R. S. (2018). The Dazzling Promise of Ketamine. Cerebrum: The Dana forum on brain science2018, cer-04-18. LINK.

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